| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:500IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your speci |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIF3A |
| Gene ID: | 11127 |
| Uniprot ID: | KIF3A_HUMAN |
| Immunogen Region: | 430-699 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 430-699 of human KIF3A (NP_008985.3). |
| Immunogen Sequence: | RKALETKLDMEEEERNKARA ELEKREKDLLKAQQEHQSLL EKLSALEKKVIVGGVDLLAK AEEQEKLLEESNMELEERRK RAEQLRRELEEKEQERLDIE EKYTSLQEEAQGKTKKLKKV WTMLMAAKSEMADLQQEHQR EIEGLLENIRQLSRELRLQM LIIDNFIPRDYQEMIENYVH WNEDIGEWQLKCVAYTGNNM RKQTPVPDKKEKDPFEVDLS HVYLAYTEESLRQSLMKLE |
| Function | Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. |
| Protein Name | Kinesin-Like Protein Kif3aMicrotubule Plus End-Directed Kinesin Motor 3a |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-2132295Reactome: R-HSA-5610787Reactome: R-HSA-5620924Reactome: R-HSA-5635838Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionCiliumMicrotubule Organizing CenterCentrosomeCentrioleLocalizes To The Subdistal Appendage Region Of The Centriole |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif3a antibodyAnti-Microtubule Plus End-Directed Kinesin Motor 3a antibodyAnti-KIF3A antibodyAnti-KIF3 antibody |
Information sourced from Uniprot.org