| Short Description : | Rabbit polyclonal KIF2A (30-220) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIF2A |
| Gene ID: | 3796 |
| Uniprot ID: | KIF2A_HUMAN |
| Immunogen Region: | 30-220 |
| Immunogen Sequence: | TSLNEDNESVTVEWIENGDT KGKEIDLESIFSLNPDLVPD EEIEPSPETPPPPASSAKVN KIVKNRRTVASIKNDPPSRD NRVVGSARARPSQFPEQSSS AQQNGSVSDISPVQAAKKEF GPPSRRKSNCVKEVEKLQEK REKRRLQQQELREKRAQDVD ATNPNYEIMCMIRDFRGSLD YRPLTTADPID |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-220 of human KIF2A (NP_004511.2). |
| Function | Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. |
| Protein Name | Kinesin-Like Protein Kif2aKinesin-2Hk2 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2132295Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-6811434Reactome: R-HSA-68877Reactome: R-HSA-9648025Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindleLocalized To The Spindle Microtubules And Spindle Poles From Prophase To MetaphaseEfficient Targeting To Spindle Microtubules And Spindle Poles Requires The Kinase Activity Of Plk1Recruited To Mitotic Spindles By Interaction With Psrc1 |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif2a antibodyAnti-Kinesin-2 antibodyAnti-Hk2 antibodyAnti-KIF2A antibodyAnti-KIF2 antibodyAnti-KNS2 antibody |
Information sourced from Uniprot.org
