| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIF22 |
| Gene ID: | 3835 |
| Uniprot ID: | KIF22_HUMAN |
| Immunogen Region: | 456-665 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 456-665 of human KIF22 (NP_015556.1). |
| Immunogen Sequence: | QGAPLLSTPKRERMVLMKTV EEKDLEIERLKTKQKELEAK MLAQKAEEKENHCPTMLRPL SHRTVTGAKPLKKAVVMPLQ LIQEQAASPNAEIHILKNKG RKRKLESLDALEPEEKAEDC WELQISPELLAHGRQKILDL LNEGSARDLRSLQRIGPKKA QLIVGWRELHGPFSQVEDLE RVEGITGKQMESFLKANILG LAAGQRCGAS |
| Tissue Specificity | Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes. |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 and leading to its subsequent proteasomal degradation. |
| Function | Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. |
| Protein Name | Kinesin-Like Protein Kif22Kinesin-Like Dna-Binding ProteinKinesin-Like Protein 4 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | NucleusCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif22 antibodyAnti-Kinesin-Like Dna-Binding Protein antibodyAnti-Kinesin-Like Protein 4 antibodyAnti-KIF22 antibodyAnti-KID antibodyAnti-KNSL4 antibody |
Information sourced from Uniprot.org