Anti-KIF11 antibody (900-1056) [S6MR] (STJ11102126)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Eg5 (900-1056) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S6MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KIF11 |
| Gene ID | 3832 |
| Uniprot ID | KIF11_HUMAN |
| Immunogen Region | 900-1056 |
| Immunogen Sequence | ETIKIGLTKLNCFLEQDLKL DIPTGTTPQRKSYLYPSTLV RTEPREHLLDQLKRKQPELL MMLNCSENNKEETIPDVDVE EAVLGQYTEEPLSQEPSVDA GVDCSSIGGVPFFQHKKSHG KDKENRGINTLERSKVEETT EHLVTKSRLPLRAQINL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 900-1056 of human EG5/KIF11 (P52732). |
Additional Info
| Post Translational Modifications | Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis.phosphorylation is required for mitotic function. Ubiquitinated at Lys-1034 by UHRF1 via 'Lys-63'-linked ubiquitin chains, leading to interaction with spindle assembly factor TPX2, thereby ensuring accurate distribution to the spindles during metaphase. |
| Function | Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface. |
| Protein Name | Kinesin-Like Protein Kif11Kinesin-Like Protein 1Kinesin-Like Spindle Protein HkspKinesin-Related Motor Protein Eg5Thyroid Receptor-Interacting Protein 5Tr-Interacting Protein 5Trip-5 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmCytoskeletonSpindle Pole |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif11 antibodyAnti-Kinesin-Like Protein 1 antibodyAnti-Kinesin-Like Spindle Protein Hksp antibodyAnti-Kinesin-Related Motor Protein Eg5 antibodyAnti-Thyroid Receptor-Interacting Protein 5 antibodyAnti-Tr-Interacting Protein 5 antibodyAnti-Trip-5 antibodyAnti-KIF11 antibodyAnti-EG5 antibodyAnti-KNSL1 antibodyAnti-TRIP5 antibody |
Information sourced from Uniprot.org