Anti-KIAA1524 antibody (681-905) (STJ114157)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KIAA1524 (681-905) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CIP2A |
| Gene ID | 57650 |
| Uniprot ID | CIP2A_HUMAN |
| Immunogen Region | 681-905 |
| Immunogen Sequence | EVERKNEELSVLLKAQQVES ERAQSDIEHLFQHNRKLESV AEEHEILTKSYMELLQRNES TEKKNKDLQITCDSLNKQIE TVKKLNESLKEQNEKSIAQL IEKEEQRKEVQNQLVDREHK LANLHQKTKVQEEKIKTLQK EREDKEETIDILRKELSRTE QIRKELSIKASSLEVQKAQL EGRLEEKESLVKLQQEELNK HSHMIAMIHSLSGGKINPET VNLSI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 681-905 of human KIAA1524 (NP_065941.2). |
Additional Info
| Tissue Specificity | Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). |
| Function | Acts as an inhibitor of protein phosphatase PP2A. Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies. Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei. Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss. |
| Protein Name | Protein Cip2aCancerous Inhibitor Of Pp2aP90 Autoantigen |
| Database Links | |
| Cellular Localisation | CytoplasmChromosomePredominantly Localizes Within The CytoplasmLocalizes To Broken Chromosomes Within Micronuclei During Interphase And Following ChromothripsisLocalization To Broken Chromosomes Is Mainly Independent Of Mdc1 |
| Alternative Antibody Names | Anti-Protein Cip2a antibodyAnti-Cancerous Inhibitor Of Pp2a antibodyAnti-P90 Autoantigen antibodyAnti-CIP2A antibodyAnti-KIAA1524 antibody |
Information sourced from Uniprot.org