Anti-KIAA0391 antibody (314-583) (STJ26245)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KIAA0391 (314-583) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRORP |
| Gene ID | 9692 |
| Uniprot ID | MRPP3_HUMAN |
| Immunogen Region | 314-583 |
| Immunogen Sequence | YPGESFAHSIKTWFESVPGK QWKGQFTTVRKSGQCSGCGK TIESIQLSPEEYECLKGKIM RDVIDGGDQYRKTTPQELKR FENFIKSRPPFDVVIDGLNV AKMFPKVRESQLLLNVVSQL AKRNLRLLVLGRKHMLRRSS QWSRDEMEEVQKQASCFFAD DISEDDPFLLYATLHSGNHC RFITRDLMRDHKACLPDAKT QRLFFKWQQGHQLAIVNRFP GSKLTFQRILSYDTVVQTT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 314-583 of human KIAA0391 (NP_055487.2). |
Additional Info
| Post Translational Modifications | Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion. |
| Function | Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends. |
| Protein Name | Mitochondrial Ribonuclease P Catalytic SubunitMitochondrial Ribonuclease P Protein 3Mitochondrial Rnase P Protein 3Protein Only Rnase P Catalytic Subunit |
| Database Links | Reactome: R-HSA-6785470Reactome: R-HSA-6787450Reactome: R-HSA-8868766 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Mitochondrial Ribonuclease P Catalytic Subunit antibodyAnti-Mitochondrial Ribonuclease P Protein 3 antibodyAnti-Mitochondrial Rnase P Protein 3 antibodyAnti-Protein Only Rnase P Catalytic Subunit antibodyAnti-PRORP antibodyAnti-KIAA0391 antibodyAnti-MRPP3 antibody |
Information sourced from Uniprot.org