| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRORP |
| Gene ID: | 9692 |
| Uniprot ID: | MRPP3_HUMAN |
| Immunogen Region: | 314-583 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 314-583 of human KIAA0391 (NP_055487.2). |
| Immunogen Sequence: | YPGESFAHSIKTWFESVPGK QWKGQFTTVRKSGQCSGCGK TIESIQLSPEEYECLKGKIM RDVIDGGDQYRKTTPQELKR FENFIKSRPPFDVVIDGLNV AKMFPKVRESQLLLNVVSQL AKRNLRLLVLGRKHMLRRSS QWSRDEMEEVQKQASCFFAD DISEDDPFLLYATLHSGNHC RFITRDLMRDHKACLPDAKT QRLFFKWQQGHQLAIVNRFP GSKLTFQRILSYDTVVQTT |
| Post Translational Modifications | Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion. |
| Function | Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends. |
| Protein Name | Mitochondrial Ribonuclease P Catalytic SubunitMitochondrial Ribonuclease P Protein 3Mitochondrial Rnase P Protein 3Protein Only Rnase P Catalytic Subunit |
| Database Links | Reactome: R-HSA-6785470Reactome: R-HSA-6787450Reactome: R-HSA-8868766 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Mitochondrial Ribonuclease P Catalytic Subunit antibodyAnti-Mitochondrial Ribonuclease P Protein 3 antibodyAnti-Mitochondrial Rnase P Protein 3 antibodyAnti-Protein Only Rnase P Catalytic Subunit antibodyAnti-PRORP antibodyAnti-KIAA0391 antibodyAnti-MRPP3 antibody |
Information sourced from Uniprot.org