| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KHDRBS3 (177-346) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KHDRBS3 |
| Gene ID: |
10656 |
| Uniprot ID: |
KHDR3_HUMAN |
| Immunogen Region: |
177-346 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 177-346 of human KHDRBS3 (NP_006549.1). |
| Immunogen Sequence: |
GSENADVPVVRGKPTLRTRG VPAPAITRGRGGVTARPVGV VVPRGTPTPRGVLSTRGPVS RGRGLLTPRARGVPPTGYRP PPPPPTQETYGEYDYDDGYG TAYDEQSYDSYDNSYSTPAQ SGADYYDYGHGLSEETYDSY GQEEWTNSRHKAPSARTAKG VYRDQPYGRY |
| Tissue Specificity | Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis. |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated. |
| Function | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-AUUAAA-3' motif in vitro. Binds optimally to RNA containing 5'-AUUAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity. May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing. Can bind FABP9 mRNA. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression. |
| Protein Name | Kh Domain-Containing - Rna-Binding - Signal Transduction-Associated Protein 3Rna-Binding Protein T-StarSam68-Like Mammalian Protein 2Slm-2Sam68-Like Phosphotyrosine Protein |
| Database Links | Reactome: R-HSA-8849468 |
| Cellular Localisation | NucleusLocalized In A Compartment Adjacent To The NucleolusBut Distinct From The Peri-Nucleolar One |
| Alternative Antibody Names | Anti-Kh Domain-Containing - Rna-Binding - Signal Transduction-Associated Protein 3 antibodyAnti-Rna-Binding Protein T-Star antibodyAnti-Sam68-Like Mammalian Protein 2 antibodyAnti-Slm-2 antibodyAnti-Sam68-Like Phosphotyrosine Protein antibodyAnti-KHDRBS3 antibodyAnti-SALP antibodyAnti-SLM2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
