• Human skin with carcinoma stained with anti-HMW, CK antibody using peroxidase-conjugate and DAB chromogen. Note membrane and cytoplasmic staining of squamous epithelium.

Anti-Keratin, HMW antibody [34 Beta E12] (STJ180151)

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STJ180151

£152.50 - £395.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Keratin, HMW is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 34 Beta E12
Conjugation: Unconjugated
Isotype: IgG1/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Specificity: Positive control: Squamous cell carcinoma, prostate
Immunogen: Solubilized keratin extracted from human stratum corneum
Background Cytokeratin 34bE12 antibody recognizes cytokeratin 1, 5, 10, and 14 in the Moll catalog (MW 68kDa, 58kDa, 56.5kDa, and 50kDa) , respectively. Cytokeratin 34bE12 antibody promises to be a specific marker useful in differential identification of squamous carcinomas from adenocarcinomas and differential diagnosis of benign and malignant tumors of prostatic gland. In normal cells, it labels squamous, ductal and other complex epithelia. It reacts with benign small-acinar lesions of the prostate and does not react with hepatocytes, pancreatic acinar cells, proximal renal tubes or endometrial glands. In tumor cells, this antibody is reactive with both squamous and ductal neoplasms and variably with those derived from simple epithelium.

Information sourced from Uniprot.org

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