• Human prostate tissue stained with anti-Keratin 5/6 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of basal cells.

Anti-Keratin 5/6 antibody [D5‐16B4] (STJ180146)

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STJ180146

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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Keratin 5/6 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: D5‐16B4
Conjugation: Unconjugated
Isotype: IgG1/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100‐200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: KRT5
Gene ID: 3852
Uniprot ID: K2C5_HUMAN
Specificity: Positive control: Mesothelioma, prostate
Immunogen: Isolated Cytokeratin 5
Tissue Specificity Expressed in corneal epithelium (at protein level). Expressed in keratinocytes (at protein level).
Post Translational Modifications Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle. Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis. CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury. O-glycosylated.
Function Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes.
Protein Name Keratin - Type Ii Cytoskeletal 5
58 Kda Cytokeratin
Cytokeratin-5
Ck-5
Keratin-5
K5
Type-Ii Keratin Kb5
Database Links Reactome: R-HSA-446107
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Keratin - Type Ii Cytoskeletal 5 antibody
Anti-58 Kda Cytokeratin antibody
Anti-Cytokeratin-5 antibody
Anti-Ck-5 antibody
Anti-Keratin-5 antibody
Anti-K5 antibody
Anti-Type-Ii Keratin Kb5 antibody
Anti-KRT5 antibody

Information sourced from Uniprot.org

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