![Anti-Keratin 18 antibody [M9] (STJ16100235)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148953/346587/STJ16100235_1__47195.1681998651.jpg?c=1 "Anti-Keratin 18 antibody [M9] (STJ16100235)")
![Anti-Keratin 18 antibody [M9] (STJ16100235)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/148953/346587/STJ16100235_1__47195.1681998651.jpg?c=1 "Anti-Keratin 18 antibody [M9] (STJ16100235)")
Anti-Keratin 18 antibody [M9] (STJ16100235)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenCytokeratin isolated from a human breast carcinoma cell line (MCF-7)
General Information
| Short Description | Mouse monoclonal anti-Keratin 18 for use in IHC-F, WB and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F/WB/FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | M9 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 15 Mu g/mL |
| Dilution Range | IHC-F 1:150IHC-P 1:10 |
| Formulation | Culture medium with 0.01M Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | KRT18 |
| Gene ID | 3875 |
| Uniprot ID | K1C18_HUMAN |
| Immunogen | Cytokeratin isolated from a human breast carcinoma cell line (MCF-7) |
Additional Info
| Tissue Specificity | Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. |
| Post Translational Modifications | Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation. |
| Function | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Protein Name | Keratin - Type I Cytoskeletal 18Cell Proliferation-Inducing Gene 46 ProteinCytokeratin-18Ck-18Keratin-18K18 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Nucleus MatrixCytoplasmPerinuclear RegionNucleusNucleolus |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 18 antibodyAnti-Cell Proliferation-Inducing Gene 46 Protein antibodyAnti-Cytokeratin-18 antibodyAnti-Ck-18 antibodyAnti-Keratin-18 antibodyAnti-K18 antibodyAnti-KRT18 antibodyAnti-CYK18 antibodyAnti-PIG46 antibody |
Information sourced from Uniprot.org