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| Host: | Mouse |
| Applications: | IP/WB/IHC-P/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Keratin 18 is suitable for use in Immunoprecipitation, Western Blot, Immunohistochemistry, Immunocytochemistry and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | DA-7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | KRT18 |
| Gene ID: | 3875 |
| Uniprot ID: | K1C18_HUMAN |
| Immunogen: | Human breast carcinoma cell line PMC-42. |
| Tissue Specificity | Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. |
| Post Translational Modifications | Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation. |
| Function | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Protein Name | Keratin - Type I Cytoskeletal 18 Cell Proliferation-Inducing Gene 46 Protein Cytokeratin-18 Ck-18 Keratin-18 K18 |
| Database Links | Reactome: R-HSA-6805567 Reactome: R-HSA-6809371 |
| Cellular Localisation | Nucleus Matrix Cytoplasm Perinuclear Region Nucleus Nucleolus |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 18 antibody Anti-Cell Proliferation-Inducing Gene 46 Protein antibody Anti-Cytokeratin-18 antibody Anti-Ck-18 antibody Anti-Keratin-18 antibody Anti-K18 antibody Anti-KRT18 antibody Anti-CYK18 antibody Anti-PIG46 antibody |
Information sourced from Uniprot.org