![Anti-Keratin 14 antibody [RCK107] (STJ16100264)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148982/346618/STJ16100264_1__16217.1681998684.png?c=1 "Anti-Keratin 14 antibody [RCK107] (STJ16100264)")
![Anti-Keratin 14 antibody [RCK107] (STJ16100264)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/148982/346618/STJ16100264_1__16217.1681998684.png?c=1 "Anti-Keratin 14 antibody [RCK107] (STJ16100264)")
Anti-Keratin 14 antibody [RCK107] (STJ16100264)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
Immunogencytoskeletal preparation of TR146 epithelial cells
General Information
| Short Description | Mouse monoclonal anti-Keratin 14 for use in FC, ICC, IHC-F and WB in Human, Dog, Rat and Swine samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/ICC/IHC-F/WB |
| Host | Mouse |
| Reactivity | Human/Dog/Rat/Swine |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RCK107 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Dilution Range | FC 1:100-1:200ICCIHC-F 1:100-1:200WB 1:100-1:1000 |
| Formulation | PBS with 0.09% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | KRT14 |
| Gene ID | 3861 |
| Uniprot ID | K1C14_HUMAN |
| Immunogen | cytoskeletal preparation of TR146 epithelial cells |
Additional Info
| Tissue Specificity | Expressed in the corneal epithelium (at protein level). Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen. |
| Post Translational Modifications | A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex. |
| Function | The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. |
| Protein Name | Keratin - Type I Cytoskeletal 14Cytokeratin-14Ck-14Keratin-14K14 |
| Database Links | Reactome: R-HSA-446107Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | CytoplasmNucleusExpressed In Both As A Filamentous Pattern |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 14 antibodyAnti-Cytokeratin-14 antibodyAnti-Ck-14 antibodyAnti-Keratin-14 antibodyAnti-K14 antibodyAnti-KRT14 antibody |
Information sourced from Uniprot.org