Anti-KDM5C antibody [2E4-E1-G8] (STJA0032337)

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STJA0032337
£133.50 - £281.50
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Host: Mouse
Applications: WB/ICC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-KDM5C for use in WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : 2E4-E1-G8
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification: Affinity Purified
Concentration: 5.7 mg/mL
Dilution Range: WB 1:500-1:1000
IF 1:50-1:200
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: KDM5C
Gene ID: 8242
Uniprot ID: KDM5C_HUMAN
Immunogen: Purified recombinant human KDM5C/Jarid1C/SMCX protein fragments expressed in E.coli
Tissue Specificity Expressed in all tissues examined. Highest levels found in brain and skeletal muscle.
Function Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Protein Name Lysine-Specific Demethylase 5c
Histone Demethylase Jarid1c
Jumonji/Arid Domain-Containing Protein 1c
Protein Smcx
Protein Xe169
Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c
Database Links Reactome: R-HSA-3214842
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Lysine-Specific Demethylase 5c antibody
Anti-Histone Demethylase Jarid1c antibody
Anti-Jumonji/Arid Domain-Containing Protein 1c antibody
Anti-Protein Smcx antibody
Anti-Protein Xe169 antibody
Anti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c antibody
Anti-KDM5C antibody
Anti-DXS1272E antibody
Anti-JARID1C antibody
Anti-SMCX antibody
Anti-XE169 antibody

Information sourced from Uniprot.org

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