| Post Translational Modifications | Ubiquitinated via 'Lys-63'-linked ubiquitin chains. Deubiquitinated by USP14 with the help of TRIM14 leading to stabilization. |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Protein Name | Lysine-Specific Demethylase 4dJmjc Domain-Containing Histone Demethylation Protein 3dJumonji Domain-Containing Protein 2dHistone H3-Trimethyl-L-Lysine(9 Demethylase 4d |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 4d antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 3d antibodyAnti-Jumonji Domain-Containing Protein 2d antibodyAnti-Histone H3-Trimethyl-L-Lysine(9 Demethylase 4d antibodyAnti-KDM4D antibodyAnti-JHDM3D antibodyAnti-JMJD2D antibody |
Information sourced from Uniprot.org
