| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KDM4C (640-830) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KDM4C |
| Gene ID: |
23081 |
| Uniprot ID: |
KDM4C_HUMAN |
| Immunogen Region: |
640-830 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 640-830 of human KDM4C (NP_055876.2). |
| Immunogen Sequence: |
RMKPHCAICTLLMPYHKPDS SNEENDARWETKLDEVVTSE GKTKPLIPEMCFIYSEENIE YSPPNAFLEEDGTSLLISCA KCCVRVHASCYGIPSHEICD GWLCARCKRNAWTAECCLCN LRGGALKQTKNNKWAHVMCA VAVPEVRFTNVPERTQIDVG RIPLQRLKLKCIFCRHRVKR VSGACIQCSYG |
| Tissue Specificity | Overexpressed in several esophageal squamous cell carcinomas (ESCs). |
| Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Protein Name | Lysine-Specific Demethylase 4cGene Amplified In Squamous Cell Carcinoma 1 ProteinGasc-1 ProteinJmjc Domain-Containing Histone Demethylation Protein 3cJumonji Domain-Containing Protein 2cHistone H3-Trimethyl-L-Lysine(9 Demethylase 4c |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5625886 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 4c antibodyAnti-Gene Amplified In Squamous Cell Carcinoma 1 Protein antibodyAnti-Gasc-1 Protein antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 3c antibodyAnti-Jumonji Domain-Containing Protein 2c antibodyAnti-Histone H3-Trimethyl-L-Lysine(9 Demethylase 4c antibodyAnti-KDM4C antibodyAnti-GASC1 antibodyAnti-JHDM3C antibodyAnti-JMJD2C antibodyAnti-KIAA0780 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
