| Tissue Specificity | Overexpressed in several esophageal squamous cell carcinomas (ESCs). |
| Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Protein Name | Lysine-Specific Demethylase 4cGene Amplified In Squamous Cell Carcinoma 1 ProteinGasc-1 ProteinJmjc Domain-Containing Histone Demethylation Protein 3cJumonji Domain-Containing Protein 2cHistone H3-Trimethyl-L-Lysine(9 Demethylase 4c |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5625886 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 4c antibodyAnti-Gene Amplified In Squamous Cell Carcinoma 1 Protein antibodyAnti-Gasc-1 Protein antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 3c antibodyAnti-Jumonji Domain-Containing Protein 2c antibodyAnti-Histone H3-Trimethyl-L-Lysine(9 Demethylase 4c antibodyAnti-KDM4C antibodyAnti-GASC1 antibodyAnti-JHDM3C antibodyAnti-JMJD2C antibodyAnti-KIAA0780 antibody |
Information sourced from Uniprot.org
