| Function | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). |
| Protein Name | Lysine-Specific Demethylase 2bCxxc-Type Zinc Finger Protein 2F-Box And Leucine-Rich Repeat Protein 10F-Box Protein Fbl10F-Box/Lrr-Repeat Protein 10Jmjc Domain-Containing Histone Demethylation Protein 1bJumonji Domain-Containing Emsy-Interactor Methyltransferase Motif ProteinProtein JemmaProtein-Containing Cxxc Domain 2Histone-H3-Lysine-36 Demethylase 1b |
| Database Links | Reactome: R-HSA-3214842 |
| Cellular Localisation | NucleusNucleolusChromosome |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 2b antibodyAnti-Cxxc-Type Zinc Finger Protein 2 antibodyAnti-F-Box And Leucine-Rich Repeat Protein 10 antibodyAnti-F-Box Protein Fbl10 antibodyAnti-F-Box/Lrr-Repeat Protein 10 antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 1b antibodyAnti-Jumonji Domain-Containing Emsy-Interactor Methyltransferase Motif Protein antibodyAnti-Protein Jemma antibodyAnti-Protein-Containing Cxxc Domain 2 antibodyAnti-Histone-H3-Lysine-36 Demethylase 1b antibodyAnti-KDM2B antibodyAnti-CXXC2 antibodyAnti-FBL10 antibodyAnti-FBXL10 antibodyAnti-JHDM1B antibodyAnti-NDY1 antibodyAnti-PCCX2 antibody |
Information sourced from Uniprot.org
