| Function | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. |
| Protein Name | Lysine-Specific Histone Demethylase 2Flavin-Containing Amine Oxidase Domain-Containing Protein 1Lysine-Specific Histone Demethylase 1b |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5689603Reactome: R-HSA-9029569 |
| Cellular Localisation | NucleusChromosomeFound In Actively Rnapolii-Transcribed Gene Bodies |
| Alternative Antibody Names | Anti-Lysine-Specific Histone Demethylase 2 antibodyAnti-Flavin-Containing Amine Oxidase Domain-Containing Protein 1 antibodyAnti-Lysine-Specific Histone Demethylase 1b antibodyAnti-KDM1B antibodyAnti-AOF1 antibodyAnti-C6orf193 antibodyAnti-LSD2 antibody |
Information sourced from Uniprot.org
