| Host: |
Goat |
| Applications: |
Pep-ELISA/WB-Trf |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-KCTD11 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
KCTD11 |
| Gene ID: |
147040 |
| Uniprot ID: |
KCD11_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_001002914.1 |
| Immunogen Sequence: |
PEVEYGRLGLQP |
| Function | Plays a role as a marker and a regulator of neuronal differentiation.Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. |
| Protein Name | Btb/Poz Domain-Containing Protein Kctd11Kcash1 ProteinPotassium Channel Tetramerization Domain-Containing Protein 11Ring-Type E3 Ubiquitin Transferase Subunit Kctd11 |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Protein Kctd11 antibodyAnti-Kcash1 Protein antibodyAnti-Potassium Channel Tetramerization Domain-Containing Protein 11 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Subunit Kctd11 antibodyAnti-KCTD11 antibodyAnti-C17orf36 antibodyAnti-REN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
