| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-KCNU1 (1100-1149 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | KCNU1 |
| Gene ID: | 157855 |
| Uniprot ID: | KCNU1_HUMAN |
| Immunogen Region: | 1100-1149 aa |
| Specificity: | Specific for KCNU1. |
| Immunogen: | A synthetic peptide from aa region 1100-1149 of human KCNU1 conjugated to blue carrier protein was used as the antigen. |
| Function | Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). Represents the primary spermatozoan K(+) current. The channel underlies a pH-triggered membrane hyperpolarization during the process of sperm capacitation, as sperm encounter the alkaline environment near the ovum in the female reproductive tract, thereby playing an essential for male fertility. |
| Protein Name | Potassium Channel Subfamily U Member 1Calcium-Activated Potassium Channel Subunit Alpha-3Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-3Kca5Slowpoke Homolog 3 |
| Database Links | Reactome: R-HSA-1300642 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCiliumFlagellum Membrane |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily U Member 1 antibodyAnti-Calcium-Activated Potassium Channel Subunit Alpha-3 antibodyAnti-Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-3 antibodyAnti-Kca5 antibodyAnti-Slowpoke Homolog 3 antibodyAnti-KCNU1 antibodyAnti-KCNMA3 antibodyAnti-KCNMC1 antibodyAnti-SLO3 antibody |
Information sourced from Uniprot.org