Anti-KCNS2 antibody (N-Term) (STJ13101666)

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STJ13101666-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Mouse/Rat/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-KCNS2 (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB (confirmed by recombinant protein). A dilution of 1:200 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: Kcns2
Gene ID: 16539
Uniprot ID: KCNS2_MOUSE
Immunogen Region: N-Term
Specificity: Specific for KCNS2.
Immunogen: A synthetic peptide from n-terminal region of mouse KCNS2 (Kv9.2) conjugated to an immunogenic carrier protein was used as the antigen.
Function Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process.
Protein Name Delayed-Rectifier Potassium Channel Regulatory Subunit Kcns2
Delayed-Rectifier K(+ Channel Alpha Subunit 2
Delayed-Rectifier Potassium Channel Subunit Kv9.2
Potassium Voltage-Gated Channel Subfamily S Member 2
Database Links Reactome: R-MMU-1296072
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
May Not Reach The Plasma Membrane But Remain In An Intracellular Compartment In The Absence Of Kcnb1 Or Kcnb2
Alternative Antibody Names Anti-Delayed-Rectifier Potassium Channel Regulatory Subunit Kcns2 antibody
Anti-Delayed-Rectifier K(+ Channel Alpha Subunit 2 antibody
Anti-Delayed-Rectifier Potassium Channel Subunit Kv9.2 antibody
Anti-Potassium Voltage-Gated Channel Subfamily S Member 2 antibody
Anti-Kcns2 antibody

Information sourced from Uniprot.org

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