• Immunofluorescence analysis of paraffin-embedded mouse eye using KCNS2 Rabbit polyclonal antibody (STJ118130) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of paraffin-embedded mouse eye using KCNS2 Rabbit polyclonal antibody (STJ118130) at dilution of 1:100 (20x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of paraffin-embedded rat eye using KCNS2 Rabbit polyclonal antibody (STJ118130) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
  • Western blot analysis of lysates from rat brain, using KCNS2 Rabbit polyclonal antibody (STJ118130) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-KCNS2 antibody (1-187) (STJ118130)

SKU:
STJ118130

£112.50 - £524.50
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IF/ICC:1:50-1:100
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCNS2
Gene ID: 3788
Uniprot ID: KCNS2_HUMAN
Immunogen Region: 1-187
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-187 of human KCNS2 (NP_065748.1).
Immunogen Sequence: MTGQSLWDVSEANVEDGEIR INVGGFKRRLRSHTLLRFPE TRLGRLLLCHSREAILELCD DYDDVQREFYFDRNPELFPY VLHFYHTGKLHVMAELCVFS FSQEIEYWGINEFFIDSCCS YSYHGRKVEPEQEKWDEQSD QESTTSSFDEILAFYNDASK FDGQPLGNFRRQLWLALDNP GYSVLSR
Function Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process.
Protein Name Delayed-Rectifier Potassium Channel Regulatory Subunit Kcns2
Delayed-Rectifier K(+ Channel Alpha Subunit 2
Delayed-Rectifier Potassium Channel Subunit Kv9.2
Potassium Voltage-Gated Channel Subfamily S Member 2
Database Links Reactome: R-HSA-1296072
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
May Not Reach The Plasma Membrane But Remain In An Intracellular Compartment In The Absence Of Kcnb1 Or Kcnb2
Alternative Antibody Names Anti-Delayed-Rectifier Potassium Channel Regulatory Subunit Kcns2 antibody
Anti-Delayed-Rectifier K(+ Channel Alpha Subunit 2 antibody
Anti-Delayed-Rectifier Potassium Channel Subunit Kv9.2 antibody
Anti-Potassium Voltage-Gated Channel Subfamily S Member 2 antibody
Anti-KCNS2 antibody
Anti-KIAA1144 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance