| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNQ2 (466-665) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNQ2 |
| Gene ID: |
3785 |
| Uniprot ID: |
KCNQ2_HUMAN |
| Immunogen Region: |
466-665 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 466-665 of human KCNQ2 (NP_742105.1). |
| Immunogen Sequence: |
SPSADQSLEDSPSKVPKSWS FGDRSRARQAFRIKGAASRQ NSEEASLPGEDIVDDKSCPC EFVTEDLTPGLKVSIRAVCV MRFLVSKRKFKESLRPYDVM DVIEQYSAGHLDMLSRIKSL QSRVDQIVGRGPAITDKDRT KGPAEAELPEDPSMMGRLGK VEKQVLSMEKKLDFLVNIYM QRMGIPPTETEAYFGAKEPE |
| Tissue Specificity | In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal cord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors. |
| Post Translational Modifications | KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that depends on phosphorylation of Ser-52 in the N-terminal region. KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation (Probable). Degradation induced by NEDD4L is inhibited by USP36. |
| Function | Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily Kqt Member 2Kqt-Like 2Neuroblastoma-Specific Potassium Channel Subunit Alpha Kvlqt2Voltage-Gated Potassium Channel Subunit Kv7.2 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-445095 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily Kqt Member 2 antibodyAnti-Kqt-Like 2 antibodyAnti-Neuroblastoma-Specific Potassium Channel Subunit Alpha Kvlqt2 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv7.2 antibodyAnti-KCNQ2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
