• Immunohistochemistry analysis of MaxiK Alpha antibody in paraffin-embedded human brain tissue.
  • Western blot analysis of lysate from HeLa cells, using MaxiK Alpha antibody.
  • Western blot analysis of various cells using MaxiK Alpha Polyclonal Antibody

Anti-KCNMA1 antibody (721-770 aa) (STJ94031)

SKU:
STJ94031

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Calcium-activated potassium channel subunit alpha-1alpha (721-770 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCNMA1
Gene ID: 3778
Uniprot ID: KCMA1_HUMAN
Immunogen Region: 721-770 aa
Specificity: MaxiK Alpha Polyclonal Antibody detects endogenous levels of MaxiK Alpha protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human MaxiKalpha at the amino acid range 721-770
Post Translational Modifications Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity. Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network.
Function Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
Protein Name Calcium-Activated Potassium Channel Subunit Alpha-1
Bk Channel
Bkca Alpha
Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1
K(Vcaalpha
Kca1.1
Maxi K Channel
Maxik
Slo-Alpha
Slo1
Slowpoke Homolog
Slo Homolog
Hslo
Database Links Reactome: R-HSA-1296052
Reactome: R-HSA-418457
Reactome: R-HSA-9662360
Reactome: R-HSA-9667769
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Calcium-Activated Potassium Channel Subunit Alpha-1 antibody
Anti-Bk Channel antibody
Anti-Bkca Alpha antibody
Anti-Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1 antibody
Anti-K(Vcaalpha antibody
Anti-Kca1.1 antibody
Anti-Maxi K Channel antibody
Anti-Maxik antibody
Anti-Slo-Alpha antibody
Anti-Slo1 antibody
Anti-Slowpoke Homolog antibody
Anti-Slo Homolog antibody
Anti-Hslo antibody
Anti-KCNMA1 antibody
Anti-KCNMA antibody
Anti-SLO antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance