Anti-KCNJ2 antibody (81-130 aa) (STJ93838)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human KCNJ2 at the amino acid range 81-130
General Information
| Short Description | Rabbit polyclonal anti-Inward rectifier potassium channel 2 channel Kir2.1 (81-130 aa) for use in WB, IHC, IF and ELISA in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNJ2 |
| Gene ID | 3759 |
| Uniprot ID | KCNJ2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human KCNJ2 at the amino acid range 81-130 |
| Immunogen Region | 81-130 aa |
| Specificity | KIR2.1 Polyclonal Antibody detects endogenous levels of KIR2.1 protein. |
Additional Info
| Post Translational Modifications | S-nitrosylation increases the open probability and inward rectifying currents. |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. |
| Protein Name | Inward Rectifier Potassium Channel 2Cardiac Inward Rectifier Potassium ChannelInward Rectifier K(+ Channel Kir2.1Irk-1Hirk1Potassium Channel - Inwardly Rectifying Subfamily J Member 2 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-1296053Reactome: R-HSA-5576886Reactome: R-HSA-9729555Reactome: R-HSA-997272 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinSarcolemmaT-Tubule |
| Alternative Antibody Names | Anti-Inward Rectifier Potassium Channel 2 antibodyAnti-Cardiac Inward Rectifier Potassium Channel antibodyAnti-Inward Rectifier K(+ Channel Kir2.1 antibodyAnti-Irk-1 antibodyAnti-Hirk1 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 2 antibodyAnti-KCNJ2 antibodyAnti-IRK1 antibody |
Information sourced from Uniprot.org