| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ATP-sensitive inward rectifier potassium channel 14 channel Kir2.4 (350-430 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KCNJ14 |
| Gene ID: | 3770 |
| Uniprot ID: | KCJ14_HUMAN |
| Immunogen Region: | 350-430 aa |
| Specificity: | IRK14 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 350-430 |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 14 Inward Rectifier K(+ Channel Kir2.4 Irk-4 Potassium Channel - Inwardly Rectifying Subfamily J Member 14 |
| Database Links | Reactome: R-HSA-1296053 Reactome: R-HSA-5576886 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 14 antibody Anti-Inward Rectifier K(+ Channel Kir2.4 antibody Anti-Irk-4 antibody Anti-Potassium Channel - Inwardly Rectifying Subfamily J Member 14 antibody Anti-KCNJ14 antibody Anti-IRK4 antibody |
Information sourced from Uniprot.org