Anti-KCNJ11 antibody (N-Term) (STJ13101673)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the n-terminal region of mouse KCNJ11 (Kir6.2) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-KCNJ11 (N-Term) for use in IHC and WB in Mouse, Rat and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Kcnj11 |
| Gene ID | 16514 |
| Uniprot ID | KCJ11_MOUSE |
| Immunogen | A synthetic peptide from the n-terminal region of mouse KCNJ11 (Kir6.2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | N-Term |
| Specificity | Specific for KCNJ11. |
Additional Info
| Function | Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. In pancreatic cells, it forms KATP channels with ABCC8/SUR1. Can form cardiac and smooth muscle-type KATP channels with ABCC9. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 11Inward Rectifier K(+ Channel Kir6.2Potassium Channel - Inwardly Rectifying Subfamily J Member 11 |
| Database Links | Reactome: R-MMU-1296025Reactome: -MMU-382556Reactome: -MMU-422356Reactome: -MMU-5578775 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 11 antibodyAnti-Inward Rectifier K(+ Channel Kir6.2 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 11 antibodyAnti-Kcnj11 antibody |
Information sourced from Uniprot.org