• Immunohistochemical analysis of paraffin-embedded human oophoroma. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-KCNJ10 antibody (160-240 aa) (STJ197464)

SKU:
STJ197464

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ATP-sensitive inward rectifier potassium channel 10 channel Kir1.2 (160-240 aa) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCNJ10
Gene ID: 3766
Uniprot ID: KCJ10_HUMAN
Immunogen Region: 160-240 aa
Specificity: This antibody detects endogenous levels of Human, Rat, Mouse Kir4.1
Immunogen: Synthesized peptide derived from the human Kir4.1 at the amino acid range 160-240
Function May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules.this process is critical for Na(+) reabsorption at the tubules.
Protein Name Atp-Sensitive Inward Rectifier Potassium Channel 10
Atp-Dependent Inwardly Rectifying Potassium Channel Kir4.1
Inward Rectifier K(+ Channel Kir1.2
Potassium Channel - Inwardly Rectifying Subfamily J Member 10
Database Links Reactome: R-HSA-1296041
Reactome: R-HSA-1296067
Reactome: R-HSA-997272
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
In Kidney Distal Convoluted Tubules
Located In The Basolateral Membrane Where It Colocalizes With Kcnj16
Alternative Antibody Names Anti-Atp-Sensitive Inward Rectifier Potassium Channel 10 antibody
Anti-Atp-Dependent Inwardly Rectifying Potassium Channel Kir4.1 antibody
Anti-Inward Rectifier K(+ Channel Kir1.2 antibody
Anti-Potassium Channel - Inwardly Rectifying Subfamily J Member 10 antibody
Anti-KCNJ10 antibody

Information sourced from Uniprot.org

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