| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNIP3 (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Kcnip3 |
| Gene ID: |
56461 |
| Uniprot ID: |
CSEN_MOUSE |
| Immunogen Region: |
N-Term |
| Specificity: |
Specific for Calsenilin. |
| Immunogen: |
A synthetic peptide from n-terminal region of mouse KCNIP3 conjugated toblue carrier protein was used as the antigen. |
| Post Translational Modifications | Palmitoylated. Palmitoylation enhances association with the plasma membrane. Proteolytically cleaved by caspase-3. |
| Function | Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception. Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. |
| Protein Name | CalsenilinA-Type Potassium Channel Modulatory Protein 3Dre-Antagonist ModulatorDreamKv Channel-Interacting Protein 3Kchip3 |
| Database Links | Reactome: R-MMU-5576894 |
| Cellular Localisation | CytoplasmCell MembraneLipid-AnchorEndoplasmic ReticulumGolgi ApparatusNucleusThe Sumoylated Form Is Present Only In The NucleusIn The Presence Of Psen2Associated With The Endoplasmic Reticulum And Golgi |
| Alternative Antibody Names | Anti-Calsenilin antibodyAnti-A-Type Potassium Channel Modulatory Protein 3 antibodyAnti-Dre-Antagonist Modulator antibodyAnti-Dream antibodyAnti-Kv Channel-Interacting Protein 3 antibodyAnti-Kchip3 antibodyAnti-Kcnip3 antibodyAnti-Csen antibodyAnti-Dream antibodyAnti-Kchip3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
