Anti-KCNIP3 antibody (169-219 aa) (STJ197369)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide derived from KChIP3 at the amino acid range 169-219
General Information
| Short Description | Rabbit polyclonal anti-Calsenilin (169-219 aa) for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNIP3 |
| Gene ID | 30818 |
| Uniprot ID | CSEN_HUMAN |
| Immunogen | Synthetic peptide derived from KChIP3 at the amino acid range 169-219 |
| Immunogen Region | 169-219 aa |
| Specificity | KChIP3 protein (A250) detects endogenous levels of KChIP3 |
Additional Info
| Post Translational Modifications | Palmitoylated. Palmitoylation enhances association with the plasma membrane. Proteolytically cleaved by caspase-3. Phosphorylation at Ser-63 inhibits cleavage by CASP3. |
| Function | Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception. Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. |
| Protein Name | CalsenilinA-Type Potassium Channel Modulatory Protein 3Dre-Antagonist ModulatorDreamKv Channel-Interacting Protein 3Kchip3 |
| Database Links | Reactome: R-HSA-5576894Reactome: R-HSA-9768777 |
| Cellular Localisation | CytoplasmCell MembraneLipid-AnchorEndoplasmic ReticulumGolgi ApparatusNucleusAlso Membrane-BoundAssociated With The Plasma MembraneIn The Presence Of Psen2 Associated With The Endoplasmic Reticulum And GolgiThe Sumoylated Form Is Present Only In The Nucleus |
| Alternative Antibody Names | Anti-Calsenilin antibodyAnti-A-Type Potassium Channel Modulatory Protein 3 antibodyAnti-Dre-Antagonist Modulator antibodyAnti-Dream antibodyAnti-Kv Channel-Interacting Protein 3 antibodyAnti-Kchip3 antibodyAnti-KCNIP3 antibodyAnti-CSEN antibodyAnti-DREAM antibodyAnti-KCHIP3 antibody |
Information sourced from Uniprot.org