| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-KCNH8 (C-Term) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | KCNH8 |
| Gene ID: | 131096 |
| Uniprot ID: | KCNH8_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | Specific for KCNH8. |
| Immunogen: | A synthetic peptide from the c-terminal of human KCNH8 (Potassium voltage-gated channel subfamily H member 8) conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials. Activation is strongly dependent on the pH of the external solution. |
| Protein Name | Voltage-Gated Delayed Rectifier Potassium Channel Kcnh8Elk1Helk-1Ether-A-Go-Go-Like Potassium Channel 3Elk Channel 3Elk3Potassium Voltage-Gated Channel Subfamily H Member 8Voltage-Gated Potassium Channel Subunit Kv12.1 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Gated Delayed Rectifier Potassium Channel Kcnh8 antibodyAnti-Elk1 antibodyAnti-Helk-1 antibodyAnti-Ether-A-Go-Go-Like Potassium Channel 3 antibodyAnti-Elk Channel 3 antibodyAnti-Elk3 antibodyAnti-Potassium Voltage-Gated Channel Subfamily H Member 8 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv12.1 antibodyAnti-KCNH8 antibody |
Information sourced from Uniprot.org
