| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow/Pig |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-KCNE3 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:1000.WB: Preliminary experiments in Human, Mouse and Rat Skeletal Muscle lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml).IHC: Paraffin embedded H |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
KCNE3 |
| Gene ID: |
10008 |
| Uniprot ID: |
KCNE3_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_005463.1 |
| Immunogen Sequence: |
PDNQTEERRASLP |
| Function | Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily E Member 3Mink-Related Peptide 2Mirp2Minimum Potassium Ion Channel-Related Peptide 2Potassium Channel Subunit Beta Mirp2 |
| Database Links | Reactome: R-HSA-5576890Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmPerikaryonCell ProjectionDendriteMembrane RaftColocalizes With Kcnb1 At High-Density Somatodendritic Clusters On The Surface Of Hippocampal Neurons |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily E Member 3 antibodyAnti-Mink-Related Peptide 2 antibodyAnti-Mirp2 antibodyAnti-Minimum Potassium Ion Channel-Related Peptide 2 antibodyAnti-Potassium Channel Subunit Beta Mirp2 antibodyAnti-KCNE3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
