| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | KCNE3 |
| Gene ID: | 10008 |
| Uniprot ID: | KCNE3_HUMAN |
| Immunogen Region: | 1-100 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNE3 (NP_005463.1). |
| Immunogen Sequence: | METTNGTETWYESLHAVLKA LNATLHSNLLCRPGPGLGPD NQTEERRASLPGRDDNSYMY ILFVMFLFAVTVGSLILGYT RSRKVDKRSDPYHVYIKNRV |
| Tissue Specificity | Expressed in hippocampal neurons (at protein level). Widely expressed with highest levels in kidney and moderate levels in small intestine. |
| Function | Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit. Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily E Member 3 Mink-Related Peptide 2 Mirp2 Minimum Potassium Ion Channel-Related Peptide 2 Potassium Channel Subunit Beta Mirp2 |
| Database Links | Reactome: R-HSA-5576890 Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cytoplasm Perikaryon Cell Projection Dendrite Membrane Raft Colocalizes With Kcnb1 At High-Density Somatodendritic Clusters On The Surface Of Hippocampal Neurons |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily E Member 3 antibody Anti-Mink-Related Peptide 2 antibody Anti-Mirp2 antibody Anti-Minimum Potassium Ion Channel-Related Peptide 2 antibody Anti-Potassium Channel Subunit Beta Mirp2 antibody Anti-KCNE3 antibody |
Information sourced from Uniprot.org