| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNC3 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:200 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
KCNC3 |
| Gene ID: |
3748 |
| Uniprot ID: |
KCNC3_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Specific for KCNC3. |
| Immunogen: |
A synthetic peptide from c-terminal region of human KCNC3 (Kv3.3) conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics. It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis. Required for normal motor function. Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex. |
| Protein Name | Voltage-Gated Potassium Channel Kcnc3KshiiidPotassium Voltage-Gated Channel Subfamily C Member 3Voltage-Gated Potassium Channel Subunit Kv3.3 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPresynaptic Cell MembranePerikaryonCell ProjectionAxonDendriteDendritic Spine MembraneCytoplasmCell CortexCytoskeletonDetected On Purkinje Cell Dendritic SpinesPositioned Perisynaptically But Also In Extrasynaptic Positions Along The Spine MembranesDetected At Presynaptic Calices Of HeldColocalizes With The Cortical Actin Cytoskeleton And The Arp2/3 Complex |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Kcnc3 antibodyAnti-Kshiiid antibodyAnti-Potassium Voltage-Gated Channel Subfamily C Member 3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv3.3 antibodyAnti-KCNC3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
