| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNC1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNC1 |
| Gene ID: |
3746 |
| Uniprot ID: |
KCNC1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNC1 (NP_004967.1). |
| Immunogen Sequence: |
MGQGDESERIVINVGGTRHQ TYRSTLRTLPGTRLAWLAEP DAHSHFDYDPRADEFFFDRH PGVFAHILNYYRTGKLHCPA DVCGPLYEEELAFWGIDETD |
| Post Translational Modifications | N-glycosylated.contains sialylated glycans. |
| Function | Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily C Member 1Ngk2Voltage-Gated Potassium Channel Subunit Kv3.1Voltage-Gated Potassium Channel Subunit Kv4 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonPresynaptic Cell MembraneLocalizes In Parallel Fiber MembranesDistributed On The Perisynaptic And Extrasynaptic Membranes Away From The Active Zones |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily C Member 1 antibodyAnti-Ngk2 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv3.1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4 antibodyAnti-KCNC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
