| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNC1 |
| Gene ID: |
3746 |
| Uniprot ID: |
KCNC1_HUMAN |
| Immunogen Region: |
1-100 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNC1 (NP_004967.1). |
| Immunogen Sequence: |
MGQGDESERIVINVGGTRHQ TYRSTLRTLPGTRLAWLAEP DAHSHFDYDPRADEFFFDRH PGVFAHILNYYRTGKLHCPA DVCGPLYEEELAFWGIDETD |
| Post Translational Modifications | N-glycosylated.contains sialylated glycans. |
| Function | Voltage-gated potassium channel that opens in response to the voltage difference across the membrane and through which potassium ions pass in accordance with their electrochemical gradient. The mechanism is time-dependent and inactivation is slow. Plays an important role in the rapid repolarization of fast-firing brain neurons. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. |
| Protein Name | Voltage-Gated Potassium Channel Kcnc1Ngk2Potassium Voltage-Gated Channel Subfamily C Member 1Voltage-Gated Potassium Channel Subunit Kv3.1Voltage-Gated Potassium Channel Subunit Kv4 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonPresynaptic Cell MembraneLocalizes In Parallel Fiber MembranesDistributed On The Perisynaptic And Extrasynaptic Membranes Away From The Active Zones |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Kcnc1 antibodyAnti-Ngk2 antibodyAnti-Potassium Voltage-Gated Channel Subfamily C Member 1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv3.1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv4 antibodyAnti-KCNC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
