| Tissue Specificity | Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle. |
| Function | Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunit. The beta-3/KCNAB3 subunit may mediate closure of potassium channels. Increases inactivation of Kv1.5/KCNA5 alpha subunit-containing channels. May display nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity. The binding of oxidized and reduced NADP(H) cofactors may be required for the regulation of potassium channel activity. |
| Protein Name | Voltage-Gated Potassium Channel Subunit Beta-3K(+ Channel Subunit Beta-3Kv-Beta-3 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Subunit Beta-3 antibodyAnti-K(+ Channel Subunit Beta-3 antibodyAnti-Kv-Beta-3 antibodyAnti-KCNAB3 antibodyAnti-KCNA3B antibody |
Information sourced from Uniprot.org
