| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNAB3 |
| Gene ID: |
9196 |
| Uniprot ID: |
KCAB3_HUMAN |
| Immunogen Region: |
285-404 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 285-404 of human KCNAB3 (NP_004723.2). |
| Immunogen Sequence: |
YPLACGLITSKYDGRVPDTC RASIKGYQWLKDKVQSEDGK KQQAKVMDLLPVAHQLGCTV AQLAIAWCLRSEGVSSVLLG VSSAEQLIEHLGALQVLSQL TPQTVMEIDGLLGNKPHSKK |
| Tissue Specificity | Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle. |
| Function | Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunit. The beta-3/KCNAB3 subunit may mediate closure of potassium channels. Increases inactivation of Kv1.5/KCNA5 alpha subunit-containing channels. May display nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity. The binding of oxidized and reduced NADP(H) cofactors may be required for the regulation of potassium channel activity. |
| Protein Name | Voltage-Gated Potassium Channel Subunit Beta-3K(+ Channel Subunit Beta-3Kv-Beta-3 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Subunit Beta-3 antibodyAnti-K(+ Channel Subunit Beta-3 antibodyAnti-Kv-Beta-3 antibodyAnti-KCNAB3 antibodyAnti-KCNA3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
