Anti-KCNAB1 antibody (N-Term) (STJ13101617)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the n-terminal of human KCNAB1 (Voltage-gated potassium channel subunit beta-1) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-KCNAB1 (N-Term) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | KCNAB1 |
| Gene ID | 7881 |
| Uniprot ID | KCAB1_HUMAN |
| Immunogen | A synthetic peptide from the n-terminal of human KCNAB1 (Voltage-gated potassium channel subunit beta-1) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | N-Term |
| Specificity | Specific for KCNAB1. |
Additional Info
| Function | Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels. Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones. The binding of NADPH is required for efficient down-regulation of potassium channel activity. Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity. Isoform KvB1.2: Isoform KvB1.2 shows no effect on KCNA1, KCNA2 or KCNB1. |
| Protein Name | Voltage-Gated Potassium Channel Subunit Beta-1K(+ Channel Subunit Beta-1Kv-Beta-1 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneRecruited To The Cytoplasmic Side Of The Cell Membrane Via Its Interaction With Pore-Forming Potassium Channel Alpha Subunits |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Subunit Beta-1 antibodyAnti-K(+ Channel Subunit Beta-1 antibodyAnti-Kv-Beta-1 antibodyAnti-KCNAB1 antibodyAnti-KCNA1B antibody |
Information sourced from Uniprot.org