Anti-KCNA4 antibody [K13/31R] (STJA0019844)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Potassium Voltage-Gated Channel Subfamily A Member 4 antibody for use in IHC, IP and WB in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IP/WB |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | K13/31R |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | KCNA4 |
| Gene ID | 3739 |
| Uniprot ID | KCNA4_HUMAN |
Additional Info
| Function | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well.channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure. Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily A Member 4Hpcn2Voltage-Gated K(+ Channel HukiiVoltage-Gated Potassium Channel Hbk4Voltage-Gated Potassium Channel Hk1Voltage-Gated Potassium Channel Subunit Kv1.4 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxon |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily A Member 4 antibodyAnti-Hpcn2 antibodyAnti-Voltage-Gated K(+ Channel Hukii antibodyAnti-Voltage-Gated Potassium Channel Hbk4 antibodyAnti-Voltage-Gated Potassium Channel Hk1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv1.4 antibodyAnti-KCNA4 antibodyAnti-KCNA4L antibody |
Information sourced from Uniprot.org