| Short Description : | Rabbit polyclonal KBTBD7 (475-684) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KBTBD7 |
| Gene ID: | 84078 |
| Uniprot ID: | KBTB7_HUMAN |
| Immunogen Region: | 475-684 |
| Immunogen Sequence: | YSFELIVVQNYLYAVNSKRM LCYDPSHNMWLNCASLKRSD FQEACVFNDEIYCICDIPVM KVYNPARGEWRRISNIPLDS ETHNYQIVNHDQKLLLITST TPQWKKNRVTVYEYDTREDQ WINIGTMLGLLQFDSGFICL CARVYPSCLEPGQSFITEED DARSESSTEWDLDGFSELDS ESGSSSSFSDDEVWVQVAPQ RNAQDQQGSL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 475-684 of human KBTBD7 (NP_115514.2). |
| Function | As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex. |
| Protein Name | Kelch Repeat And Btb Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-5658442Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Kelch Repeat And Btb Domain-Containing Protein 7 antibodyAnti-KBTBD7 antibody |
Information sourced from Uniprot.org
