| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KBTBD7 |
| Gene ID: | 84078 |
| Uniprot ID: | KBTB7_HUMAN |
| Immunogen Region: | 475-684 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 475-684 of human KBTBD7 (NP_115514.2). |
| Immunogen Sequence: | YSFELIVVQNYLYAVNSKRM LCYDPSHNMWLNCASLKRSD FQEACVFNDEIYCICDIPVM KVYNPARGEWRRISNIPLDS ETHNYQIVNHDQKLLLITST TPQWKKNRVTVYEYDTREDQ WINIGTMLGLLQFDSGFICL CARVYPSCLEPGQSFITEED DARSESSTEWDLDGFSELDS ESGSSSSFSDDEVWVQVAPQ RNAQDQQGSL |
| Function | As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex. |
| Protein Name | Kelch Repeat And Btb Domain-Containing Protein 7 |
| Database Links | Reactome: R-HSA-5658442Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Kelch Repeat And Btb Domain-Containing Protein 7 antibodyAnti-KBTBD7 antibody |
Information sourced from Uniprot.org