Anti-KATNB1 antibody (400-500) (STJ11104153)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Katanin P80 Wd40 Repeat-Containing Subunit B1 (400-500) antibody for use in WB, IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KATNB1 |
| Gene ID | 10300 |
| Uniprot ID | KTNB1_HUMAN |
| Immunogen Region | 400-500 |
| Immunogen Sequence | SEPFPAPPEDDAATAKEAAK PSPAMDVQFPVPNLEVLPRP PVVASTPAPKAEPAIIPATR NEPIGLKASDFLPAVKIPQQ AELVDEDAMSQIRKGHDTMC V |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human KATNB1 (NP_005877.2). |
Additional Info
| Function | Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. |
| Protein Name | Katanin P80 Wd40 Repeat-Containing Subunit B1Katanin P80 Subunit B1P80 Katanin |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindlePredominantly CytoplasmicLocalized To The Interphase Centrosome And Mitotic Spindle PolesLocalizes Within The CytoplasmPartially Overlapping With MicrotubulesIn Interphase And To The Mitotic Spindle And Spindle Poles During Mitosis |
| Alternative Antibody Names | Anti-Katanin P80 Wd40 Repeat-Containing Subunit B1 antibodyAnti-Katanin P80 Subunit B1 antibodyAnti-P80 Katanin antibodyAnti-KATNB1 antibody |
Information sourced from Uniprot.org