| Function | Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. |
| Protein Name | Katanin P80 Wd40 Repeat-Containing Subunit B1Katanin P80 Subunit B1P80 Katanin |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindlePredominantly CytoplasmicLocalized To The Interphase Centrosome And Mitotic Spindle PolesLocalizes Within The CytoplasmPartially Overlapping With MicrotubulesIn Interphase And To The Mitotic Spindle And Spindle Poles During Mitosis |
| Alternative Antibody Names | Anti-Katanin P80 Wd40 Repeat-Containing Subunit B1 antibodyAnti-Katanin P80 Subunit B1 antibodyAnti-P80 Katanin antibodyAnti-KATNB1 antibody |
Information sourced from Uniprot.org
