Anti-KARS1/Lysyl-tRNA synthetase antibody [SAA1945] (STJA0020373)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Lysine--Trna Ligase antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1945 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | KARS1 |
| Gene ID | 3735 |
| Uniprot ID | SYK_HUMAN |
Additional Info
| Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. |
| Protein Name | Lysine--Trna LigaseLysyl-Trna SynthetaseLysrs |
| Database Links | Reactome: R-HSA-2408522Reactome: R-HSA-379716Reactome: R-HSA-379726Reactome: R-HSA-9856649 |
| Cellular Localisation | Isoform Cytoplasmic: CytoplasmCytosolCytoplasmNucleusCell MembranePeripheral Membrane ProteinSecretedSecretion Is Induced By Tnf-AlphaCytosolic In Quiescent Mast CellsTranslocates Into The Nucleus In Response To Mast Cell Activation By Immunoglobulin EIsoform Mitochondrial: Mitochondrion |
| Alternative Antibody Names | Anti-Lysine--Trna Ligase antibodyAnti-Lysyl-Trna Synthetase antibodyAnti-Lysrs antibodyAnti-KARS1 antibodyAnti-KARS antibodyAnti-KIAA0070 antibody |
Information sourced from Uniprot.org