| Function | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. The NSL complex also acts as a regulator of gene expression in mitochondria. Within the NSL complex, KANSL3 is required to promote KAT8 association with mitochondrial DNA. Required for transcription of intraciliary transport genes in both ciliated and non-ciliated cells. This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Also required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA. Plays an essential role in spindle assembly during mitosis. Acts as a microtubule minus-end binding protein which stabilizes microtubules and promotes their assembly. Indispensable during early embryonic development where it is required for proper lineage specification and maintenance during peri-implantation development and is essential for implantation. |
| Protein Name | Kat8 Regulatory Nsl Complex Subunit 3Nsl Complex Protein Nsl3Non-Specific Lethal 3 HomologSerum Inhibited-Related ProteinTestis Development Protein Prtd |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusMitochondrionCytoplasmCytoskeletonSpindle PoleConcentrated In The Nucleus During Interphase But Displays A Marked Relocalization To The Spindle Poles During Mitosis |
| Alternative Antibody Names | Anti-Kat8 Regulatory Nsl Complex Subunit 3 antibodyAnti-Nsl Complex Protein Nsl3 antibodyAnti-Non-Specific Lethal 3 Homolog antibodyAnti-Serum Inhibited-Related Protein antibodyAnti-Testis Development Protein Prtd antibodyAnti-KANSL3 antibodyAnti-KIAA1310 antibodyAnti-NSL3 antibodyAnti-PRTD antibodyAnti-SI1 antibody |
Information sourced from Uniprot.org
