| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | JOSD1 |
| Gene ID: | 9929 |
| Uniprot ID: | JOS1_HUMAN |
| Immunogen Region: | 1-202 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human JOSD1 (NP_055691.1). |
| Immunogen Sequence: | MSCVPWKGDKAKSESLELPQ AAPPQIYHEKQRRELCALHA LNNVFQDSNAFTRDTLQEIF QRLSPNTMVTPHKKSMLGNG NYDVNVIMAALQTKGYEAVW WDKRRDVGVIALTNVMGFIM NLPSSLCWGPLKLPLKRQHW ICVREVGGAYYNLDSKLKMP EWIGGESELRKFLKHHLRGK NCELLLVVPEEVEAHQSWRT DV |
| Post Translational Modifications | Monoubiquitinated. Ubiquitination activates deubiquitination activity in vitro. |
| Function | Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. |
| Protein Name | Josephin-1Josephin Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5689877 |
| Cellular Localisation | Cell MembraneCytoplasmUbiquitination Increases Localization The Plasma MembraneIn The CytosolThe Unubiquitinated Form May Be Associated With The Cytoskeleton Via Actb-Binding |
| Alternative Antibody Names | Anti-Josephin-1 antibodyAnti-Josephin Domain-Containing Protein 1 antibodyAnti-JOSD1 antibodyAnti-JSPH1 antibodyAnti-KIAA0063 antibody |
Information sourced from Uniprot.org