| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | JDP2 |
| Gene ID: | 122953 |
| Uniprot ID: | JDP2_HUMAN |
| Immunogen Region: | 1-174 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human JDP2 (NP_001128521.1). |
| Immunogen Sequence: | MVAGWPATPPAMMPGQIPDP SVTTGSLPGLGPLTGLPSSA LTVEELKYADIRNLGAMIAP LHFLEVKLGKRPQPVKSELD EEEERRKRRREKNKVAAARC RNKKKERTEFLQRESERLEL MNAELKTQIEELKQERQQLI LMLNRHRPTCIVRTDSVKTP ESEGNPLLEQLEKK |
| Post Translational Modifications | Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments. Polyubiquitinated.probably by IRF2BP1. |
| Function | Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. |
| Protein Name | Jun Dimerization Protein 2 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Jun Dimerization Protein 2 antibodyAnti-JDP2 antibody |
Information sourced from Uniprot.org