• Immunohistochemical analysis of paraffin-embedded mouse-lung, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded mouse-lung, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded rat-lung, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded rat-lung, antibody was diluted at 1:100
  • Western blot analysis of K562 cells using JAM-B Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-JAM2 antibody (Internal) (STJ96480)

SKU:
STJ96480

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Junctional adhesion molecule B (Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: JAM2
Gene ID: 58494
Uniprot ID: JAM2_HUMAN
Immunogen Region: Internal
Specificity: JAM-B Polyclonal Antibody detects endogenous levels of JAM-B protein.
Immunogen: Synthesized peptide derived from the Internal region of human JAM-B.
Function Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons. During myogenesis, it is involved in myocyte fusion. May also play a role in angiogenesis.
Protein Name Junctional Adhesion Molecule B
Jam-B
Junctional Adhesion Molecule 2
Jam-2
Vascular Endothelial Junction-Associated Molecule
Ve-Jam
Cd Antigen Cd322
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-216083
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Tight Junction
Localized At Tight Junctions Of Both Epithelial And Endothelial Cells
Specifically Localized Within The Somatodendritic Compartment Of Neurons And Excluded From The Axon
Alternative Antibody Names Anti-Junctional Adhesion Molecule B antibody
Anti-Jam-B antibody
Anti-Junctional Adhesion Molecule 2 antibody
Anti-Jam-2 antibody
Anti-Vascular Endothelial Junction-Associated Molecule antibody
Anti-Ve-Jam antibody
Anti-Cd Antigen Cd322 antibody
Anti-JAM2 antibody
Anti-C21orf43 antibody
Anti-VEJAM antibody
Anti-UNQ219 antibody
Anti-PRO245 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance