| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein Jade-1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | JADE1 |
| Gene ID: | 79960 |
| Uniprot ID: | JADE1_HUMAN |
| Specificity: | This antibody detects endogenous levels of PHF17 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human PHF17 |
| Function | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling.at least in part, cooperates with NPHP4 in this function. |
| Protein Name | Protein Jade-1 Jade Family Phd Finger Protein 1 Phd Finger Protein 17 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus Chromosome Cytoplasm Cytoskeleton Cilium Basal Body Localizes To The Ciliary Transition Zone |
| Alternative Antibody Names | Anti-Protein Jade-1 antibody Anti-Jade Family Phd Finger Protein 1 antibody Anti-Phd Finger Protein 17 antibody Anti-JADE1 antibody Anti-KIAA1807 antibody Anti-PHF17 antibody |
Information sourced from Uniprot.org